Why Hyaluronic Acid Supplements Should be Part of Your Skin Care Routine

Hyaluronic acid is a glycosaminoglycan, a type of molecule made up of repeating disaccharide units, that is found throughout the body, including in the skin, connective tissues, and joints. It is synthesized by cells called hyaluronic acid synthases and plays a crucial role in maintaining the structure and function of tissues while improving skin health.

Skin Hydration

In the skin, hyaluronic acid acts as a humectant, meaning it attracts and holds onto water molecules, helping to keep the skin hydrated and plump. It is also involved in the synthesis and maintenance of collagen, a protein that gives skin its elasticity and strength. As we age, the body's production of hyaluronic acid and collagen decreases, leading to the appearance of fine lines and wrinkles and the loss of elasticity.

Connective Tissue and Healthy Joints

In addition to its effects on the skin, hyaluronic acid has a number of other important functions in the body. It acts as a lubricant in the joints, allowing for smooth, pain-free movement, and is involved in the repair of damaged tissue. It also plays a role in the immune system, helping to protect against infection and inflammation.

The use of Hyaluronic acid as a treatment for various conditions, including skin aging and joint problems, has gained popularity in recent years. It is available in a variety of forms, including injectable fillers, topical creams and serums, and oral supplements. In this blog post, we will focus on the use of oral hyaluronic acid supplements for the skin.

Physiological Actions of the Best Hyaluronic Acid Supplements

After oral ingestion, hyaluronic acid is absorbed from the small intestine and transported via the bloodstream to various tissues in the body. Once it reaches the target tissue, it can perform a variety of functions depending on its location such as:

• Increase the production of synovial fluid

• Promote cell proliferation of fibroblasts

• Promote the production of keratinocytes

• Stimulates the production of collagen and elastin

Hyaluronic Acid's Function in the Joints

When transported to the connective tissues of the joints, hyaluronic acid performs as a high quality biological lubricant, by reducing the friction between joint surfaces.

The viscosity, or thickness, of the synovial fluid is influenced by the concentration of hyaluronic acid. In general, an increase in hyaluronic acid concentration leads to an increase in viscosity, while a decrease in hyaluronic acid concentration leads to a decrease in viscosity.

This is important because the viscosity of the synovial fluid plays a role in the cushioning and lubrication of the components that make up the structure of the joints.

If the viscosity is too low, the joint may not be adequately lubricated and protected, leading to wear and tear and the development of osteoarthritis. On the other hand, if the viscosity is too high, the joint may become stiff and movement may be impaired (which would require an extraordinarily high level of hyaluronic acid).

In people with osteoarthritis, the concentration of hyaluronic acid in the synovial fluid is often decreased, leading to a reduction in viscosity. Supplementation with hyaluronic acid has been shown to increase the viscosity of the synovial fluid and improve joint function in people with osteoarthritis who have significant joint problems.

Hyaluronic Acid's Function in the Skin

When transported to the regions of the skin, hyaluronic acid can have a variety of effects on cell proliferation, depending on the specific tissue and cell type. In general, it have been shown to stimulate the proliferation of fibroblasts, a type of cell involved in the production of extracellular matrix components that contribute to skin health.

In a study of human dermal fibroblasts, the effects of a hyaluronic acid supplement were found to stimulate cell proliferation in a dose-dependent manner. This suggests that the more hyaluronic acid present, the greater the stimulatory effect on fibroblast proliferation.

Hyaluronic acid has also been shown to stimulate the proliferation of keratinocytes, the primary cell type in the epidermis, or outer layer of the skin. This can help to dramatically improve the overall health and appearance of the skin.

Importance of Fibroblast Cells

Fibroblasts are a type of cell found in connective tissues throughout the body. They are responsible for the production of various extracellular matrix (ECM) components, including collagen and elastin.

Collagen, a structural protein, provides strength and support to the skin and other tissues, while, elastin, a protein that gives elasticity and flexibility, is responsible for the resilience and elasticity of the skin.

Fibroblasts are essential for the repair and maintenance of various structures in the body, including the skin, tendons, ligaments, and blood vessels. They are also critical for wound healing as they are responsible for producing the extracellular matrix that is needed to repair damaged tissue.

In addition, fibroblasts play a key role in the production of new blood vessels(angiogenesis) which are important in wound healing and tissue repair.

Furthermore, fibroblasts are active in maintaining healthy skin by stimulating collagen and elastin production, keeping the skin firm, supple and resilient.

With the aging process, fibroblasts activity declines leading to wrinkles, fine lines, loss of elasticity and less youthful appearance. This is where hyaluronic acid, which is also produced by fibroblasts, comes in, as it has been shown to improve the appearance of aging skin.

Extracellular Matrix and Its Components

The extracellular matrix is the non-cellular building blocks of the tissues that surrounds and supports the cells in the body. It is a complex network of structural proteins, glycoproteins, and polysaccharides that provides mechanical and biochemical support to the cells.

The ECM also plays a role in cell signaling, cell migration and differentiation, tissue repair and maintenance, and the prevention of cancer invasion.

The ECM is composed of several different types of molecules, including collagen, elastin, and hyaluronic acid.

• Collagen

Collagen is a fibrous protein that is the main structural component of connective tissues throughout the human body. Collagen provides strength, support, and elasticity to various tissues, including skin, bones, tendons, ligaments, and cartilage.

In the skin, collagen fibers help to give it a firm and youthful appearance by providing a scaffold that supports the skin's structure and helps to prevent wrinkles and sagging. Collagen is also important for the health of hair and nails, providing strength and structural support to these tissues.

Collagen and Aging

Collagen is a very important protein in the human body and it is the most abundant protein in mammals. As we age, the body's production of collagen decreases, which can lead to wrinkles, thinning skin, and weaker bones.

• Elastin

Elastin is a fibrous protein that is found in connective tissues in the human body. It's responsible for providing elasticity and resilience to various tissues, allowing them to stretch and then return to their original shape.

Elastin fibers are found in many places throughout the body, including the skin, blood vessels, lungs, and ligaments. In the skin, elastin fibers help give it the ability to stretch and move without tearing or breaking. In blood vessels, elastin fibers allow the vessels to expand and contract with each heartbeat. In the lungs, elastin fibers allow the airways to stretch and move as we breathe. In ligaments, elastin fibers give them the ability to stretch and provide support to the joints.

Elastin and Aging

As we age, the body's production of elastin fibers decreases, which can lead to the skin losing its elasticity, the blood vessels become less flexible, the airways in the lungs lose their ability to stretch and move, and the ligaments lose their flexibility. This can contribute to wrinkles, sagging skin and deteriorating skin health, hypertension and increased susceptibility to injury.

Benefits Of Oral Hyaluronic Acid Supplements for the Skin

• Improves Hydration and Skin Elasticity

One of the main benefits of Hyaluronic acid for the skin is its ability to attract and retain water, keeping the skin hydrated. This can help to reduce the appearance age-related lines and wrinkles, giving the skin a more youthful, radiant appearance.

In a double-blind, randomized, placebo-controlled clinical trial, oral supplementation with hyaluronic acid was found to significantly improve skin moisture and elasticity in women with dry skin.

Another study found Hyaluronic acid to improve the firmness and toning of the skin. This effect is likely due to its role in the synthesis of collagen, which gives skin its elasticity and strength.

• Reduces Inflammation and Redness

Hyaluronic acid has anti-inflammatory properties that can help to reduce redness and irritation in the skin. This makes it an excellent choice for those with sensitive skin or conditions such as rosacea.

In a randomized, double-blind, placebo-controlled clinical trial, oral supplementation with hyaluronic acid was found to significantly reduce erythema (redness) and skin sensitivity in women with sensitive skin.

• Promotes Healing

Hyaluronic acid can aid in the healing process of the skin by helping to repair damaged tissue. This can be particularly beneficial for those with wounds, burns, or scars.

In a study of mice with full-thickness excisional wounds, topical application of hyaluronic acid was found to significantly increase the rate of wound closure and collagen synthesis, leading to improved scar appearance.

• Protects Against External Stressors

Taking hyaluronic acid supplements can also provide some protection for the skin against environmental stressors such as pollution and UV radiation. It does this by forming a protective barrier on the skin's surface that helps to keep harmful substances out and moisture in.

• Reduces the Appearance of Acne Scars

Hyaluronic acid can help to reduce the appearance of acne scars by promoting the production of collagen, a protein that helps to smooth out the skin and fill in depressed areas.

Hyaluronic Acid Supplements and Water Retention

One of the key properties of hyaluronic acid is its ability to exceptionally hold onto moisture like no other molecule. What is amazing is that hyaluronic acid has been shown to hold onto 1000 times its weight in water.

This ability is due to the chemical structure of hyaluronic acid, which is composed of long chains of sugars that are able to bind to water molecules.

The ability of hyaluronic acid to hold onto moisture is thought to be one of the reasons why it is such an effective ingredient in skin care products.

The study that demonstrated hyaluronic acid's ability to hold 1000 times its weight in water was published in the international Journal of Biological Sciences in 2015.

The authors of the study conducted a review of the available literature on hyaluronic acid and its effects on the skin. They analyzed a variety of studies that had been conducted on hyaluronic acid, including in vitro (laboratory) studies and clinical trials involving human subjects.

High Molecular Weight of Hyaluronic Acid

It is important to address the molecular weight of hyaluronic acid and how it relates to promoting skin and joint health.

Molecular weight is a measure of the size of a molecule. It is calculated by adding up the atomic weights of all the atoms in a molecule. Molecular weight is typically expressed in daltons (da) or grams per mole (g/mol).

Hyaluronic acid can have a wide range of molecular weights, ranging from a few hundred thousand daltons to over a million daltons. The molecular weight of hyaluronic acid can affect its ability to penetrate the skin and its overall effectiveness as a skin care ingredient.

For example, lower molecular weight hyaluronic acid may be more easily absorbed into the skin and may have a more immediate hydrating effect, while higher molecular weight hyaluronic acid may have a longer lasting hydrating effect.

Best Hyaluronic Acid Supplements Dosage

The recommended dosage of hyaluronic acid supplements taken orally may vary depending on the specific product and the individual's age, weight, and health status. It is important to follow the dosage instructions on the product label or as directed by a healthcare professional.

Hyaluronic acid supplements are available in doses ranging from 50 to 200 mg per capsule (serving). Some studies have used doses of up to 500 mg per day, but it is not clear if higher doses provide additional benefits.

It is generally recommended to start with a lower dose and gradually increase to the recommended dose over the course of several weeks. This can help to minimize any potential side effects and allow the body time to adjust to the supplement routine.

It is also important to note that hyaluronic acid supplements may interact with certain medications and may not be suitable for everyone. It is important to speak with a healthcare professional before starting any supplement routine or regimen to ensure it is safe and appropriate for you.

What Foods Contain Hyaluronic Acid?

Hyaluronic acid is not found naturally in foods in significant amounts. However, some foods contain precursors to hyaluronic acid.

Here are a few examples of foods that may support the body's production of hyaluronic acid.

• Bone broth: Bone broth is made by simmering animal bones and connective tissues in water for an extended period of time. It is a rich source of collagen, which is converted into hyaluronic acid in the body.

• Carrots and sweet potatoes: These foods are high in beta-carotene, which is converted into vitamin A in the body. Vitamin A is necessary for the production of collagen.

• Oysters: Oysters are a good source of zinc, which plays a key role in collagen and hyaluronic acid production.

• Citrus fruits: These fruits are high in vitamin C, a key component for the production of collagen/hyaluronic acid.

Keep in mind that while these are examples of foods that support the production of hyaluronic acid in the body, they are not a significant source of hyaluronic acid on their own. To optimize your intake, it will be necessary to take a hyaluronic acid supplement.

Vitamin C vs. Hyaluronic Acid

Vitamin C, also known as ascorbic acid, is a key nutrient that is involved in the production of collagen. It acts as a cofactor in the enzymatic process that converts procollagen, a precursor protein, into collagen. Vitamin C also works as an antioxidant that helps protect collagen fibers from damage caused by free radicals (molecules that can cause damage to healthy cells).

Retinol Vs. Hyaluronic Acid

Retinol is a form of vitamin A that is commonly used in anti-aging skin care products. It is believed to improve the appearance of fine lines and wrinkles, uneven skin tone, and rough texture by increasing the production of collagen and promoting cell turnover.

Retinol is available in a variety of concentrations and formulations, and it is typically used in creams, serums, and peels.

Hyaluronic acid is a large, lubricating molecule that is present in various tissues in the body, particularly the skin. It is known for its ability to hold onto moisture, which makes it a popular ingredient in moisturizing products.

One key difference between retinol and hyaluronic acid is their mechanism of action. Retinol works by increasing collagen production and promoting cell turnover, while hyaluronic acid works by attracting and retaining moisture in the skin. Another difference is that retinol may be more irritating to the skin than hyaluronic acid, especially at higher concentrations

Glycolic Acid vs. Hyaluronic Acid

Glycolic acid is an alpha hydroxy acid (AHA) that is derived from sugar cane. It is commonly used in chemical peels and exfoliating products to improve the appearance of your skin health.

Glycolic acid works by exfoliating the outer layers of the skin, which can help to improve the appearance of fine lines and wrinkles, uneven skin tone, and rough texture. It is also available in a variety of options including creams, serums, and peels.

The key difference between hyaluronic acid and glycolic acid is their manner of operation. Hyaluronic acid works by attracting and retaining moisture in the skin and tissues, while glycolic acid works by exfoliating the outer layers of the skin.

Niacinamide vs. Hyaluronic Acid

Niacinamide, also known as vitamin B3, is a water-soluble vitamin that is found in a variety of foods, including meat, fish, and legumes. It is commonly used in skin care products for its potential anti-aging and skin-soothing effects. Niacinamide is available in a variety of formulations including oral supplements, creams, serums and moisturizers.

Niacinamide works by inhibiting the transfer of melanin (a pigment that gives color to the skin) and improving the skin's barrier function. Niacinamide is more suitable for individuals with oily or acne-prone skin, as it has been shown to have a sebum-reducing effect. Niacinamaide (by itself) may also be more effective at improving the appearance of uneven skin tone and reducing the onset of acne.

Sodium Hyaluronate vs Hyaluronic Acid

Sodium hyaluronate is a salt form of hyaluronic acid that is used as the oral format for absorption. It is produced by breaking down hyaluronic acid into smaller fragments and then sodium is added to it. Sodium hyaluronate is typically smaller in size and has lower molecular weight than hyaluronic acid.

Due to its smaller size and lower molecular weight, sodium hyaluronate may be more easily absorbed into the skin and may have more immediate hydrating effect. The best hyaluronic acid supplements generally use sodium hyaluronate to be taken orally.

Recap 

Hyaluronic acid is a large, lubricating molecule that is present in various tissues in the body, including the skin, joints, and eyes. It is known for its ability to hold onto moisture, which gives it a variety of important functions in the body.

In the skin, hyaluronic acid plays a key role in maintaining the moisture content and supporting the synthesis of collagen. As we age, the levels of hyaluronic acid in the skin tend to decline, which may contribute to the appearance of prominent lines and wrinkles and the loss of skin elasticity.

There is a large body of evidence that suggest the use of supplement products containing hyaluronic acid or an isolated hyaluronic acid supplement may help to improve the appearance of aging skin and reduce the severity of wrinkles. It may also have anti-inflammatory effects, which may make it a useful treatment for acne.

Hyaluronic acid supplements can also be an effective treatment for reducing joint pain and improving mobility, especially in individuals with osteoarthritis.

Conclusion

Hyaluronic acid is a molecule with a variety of important functions in the body. It has shown to have remarkable benefits for the skin and joints, and it is available in a variety of formats, including topical products and oral supplements. Adding hyaluronic acid to your skin care routine may be a highly effective method to improving your skin health.

Frequently Asked Questions (FAQs)

1. What is hyaluronic acid and what is it used for?

Hyaluronic acid is a large, lubricating molecule that is present in various tissues in the body, including the skin. It is known for its ability to hold onto moisture, which makes it a popular ingredient in skin moisturizing products. In addition, to its hydrating properties, hyaluronic acid may also improve the appearance of fine lines and wrinkles while elasticizing the skin.

2. What are the best hyaluronic acid supplements for the skin?

There are many hyaluronic acid supplements on the market that claim to promote healthy skin.

When looking for the best hyaluronic acid supplements, search for products that are formulated with high-quality ingredients and/or combined with other clinically studied ingredients that work in sync with hyaluronic acid (such as turmeric, ginger root extract, and beta-carotene). Also, check if the supplements have been tested for purity and effectiveness.

3. How do I choose the best hyaluronic acid supplements?

When choosing the best hyaluronic acid supplement, consider the following criteria:

• Quality of ingredients: Look for supplements that are formulated with high-quality, pure ingredients

• Look for a hyaluronic acid supplement that also contain other effective, natural skin nourishing ingredient such as: Turmeric extract, ginger root extract, vitamin A as beta-carotene, and other ingredients that promote blood flow.

• Safety: Make sure the supplement has been tested for safety and purity.

• Dosage: Choose a supplement that provides the appropriate dosage of hyaluronic acid: 50-200mg per perving. Check on how many milligrams contained in the supplement listed on the label.

4. What are the potential benefits of taking hyaluronic acid supplements?

Some potential benefits of taking a hyaluronic acid supplement include:

• Improved skin hydration and appearance

• Reduced appearance of fine lines and wrinkles

• Improved skin elasticity

• Increased joint lubrication and reduced joint pain

5. Is taking Hyaluronic acid orally safe?

Overall, yes, hyaluronic acid is a safe supplement to take orally when taken as directed.

6. How do I take hyaluronic acid for healthy skin and joints?

Hyaluronic acid is typically taken orally as a supplement either as a capsule or soft gel. There are also topical and injectable formats available depending on your specific needs. Follow the dosage instructions provided by the manufacturer or as instructed by your physician.

7. What are the potential side effects of taking a hyaluronic acid supplement?

Possible side effects of hyaluronic acid pills are relatively mild and may include:

• Upset stomach

• Diarrea

• Allergic reactions

• Joint Swelling

8. Are there any interactions between hyaluronic acid nutritional supplements and other medications?

It is always a good idea to consult a healthcare practitioner if you are unsure of new supplement routines. A hyaluronic acid supplement may interact with certain medications, such as blood thinners. If you are on medication then you should definitely speak with your prescribing physician.

9. What is the best hyaluronic acid for men's face?

When it comes to finding the best hyaluronic acid for men's face, it is important to consider the same factors as mentioned above, including the quality of ingredients, other effective ingredients contained within the supplement, the product's effectiveness, and if any potential side effects are present.

The supplement formulated by EN-1 is designed to help improve the skin (including of the face) for men and women.

10. What is synovial fluid?

Synovial fluid is a clear, thick fluid that acts as a lubricant and shock absorber in joints. It is produced by the synovial membrane, which is a thin layer of tissue that lines the joint cavity.

The main function of synovial fluid is to reduce friction and to provide nutrients to the joint cartilage. It also helps to cushion the joint during movement and absorb shock, which helps to protect the joint from wear and tear.

Synovial fluid is composed of several components, including hyaluronic acid, which helps to maintain the viscosity and lubricating properties of the fluid. It is also rich in nutrients, such as amino acids and glucose, which help to nourish the joint cartilage.

In addition to its role in joints, synovial fluid can also be found in other areas of the body, such as the bursae (small fluid-filled sacs that reduce friction between muscles and bones) and the tendon sheaths (sheaths that surround tendons and help them glide smoothly).

11. Is Hyaluronic acid good for acne?

Acne is a common skin condition that is caused by a variety of factors, including diet, overproduction of oil, clogged pores, and inflammation. The presence of inflammation in acne-affected skin is thought to contribute to the development of pimples and other lesions.

There is limited research on the use of hyaluronic acid for the treatment of acne. Some studies have suggested that it may be effective in reducing inflammation and improving the appearance of acne-affected skin.

However, more research is need to to fully understand the potential benefits of hyaluronic acid for the treatment of acne and to determine what (if any) an optimal dosage would be.

12. What is the difference between collagen and elastin?

The key difference between collagen and elastin is their chemical composition. Collagen is composed of long chains of amino acids called tropocollagen, which are cross-linked and form a stable structure. Elastin, in contrast, is composed of shorter chains of amino acids called elastin peptides that are rich in the amino acids such as glycine, proline and alanine, and have a more flexible and disordered structure.

Collagen Fibers

Collagen is a type of fibrous protein that is made up of long, string-like fibers that are bundled together. These fibers provide strength, support, and elasticity to various tissues. Collagen fibers are not very flexible and do not stretch very much, but they are extremely strong and durable.

Elastin Fibers

Elastin, on the other hand, is a different type of fibrous protein that is made up of shorter, more flexible fibers. Elastic fibers are highly flexible and can stretch to several times their original length, which makes them useful in tissues that need to be flexible, such as skin and blood vessels.

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